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Miranda M. Lim, MD, PhD
lmir @ ohsu . edu
(503) 220-8262 ext 57404
(503) 402-2823 (fax)
Portland VA Medical Center
3710 SW Veterans Hospital Rd
Building 101, Rm 404A
Mail code: P3-RD42
Portland, OR 97239
OHSU
3181 SW Sam Jackson Park Rd
Portland, OR 97239
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Welcome to the Lim Laboratory

Recent Highlights

  • 2017: Funded by the Department of Defense
    • Photosensitivity and pain in complex traumatic brain injury
    • Mapping the neural circuitry of trauma-associated sleep disturbances in mice
  • 2016: Funded by the Collins Medical Trust
    • Investigating a developmental role for the neuropathology of autism
  • 2016: Funded by the VA SPiRE Award, RR&D
    • Sleep-EEG predictors of functional outcome after TBI
  • 2015: Funded by The Brain & Behavior Foundation, NARSAD Young Investigator Award
    • The impact of sleep disturbance in autism-like social behavior in voles
  • 2015: Funded by the VA Career Development Award, BLR&D
    • Sleep-wake disturbances in traumatic brain injury

The Team

Lab Lunch 2018/06/18
Left to right: Miranda, Nadir, Kris, Alisha, Randall, Carolyn, Chau, Tai, Alex, Jon, Natasha, Peyton, Mara, Kendall, Dennis, Ryan * Not pictured: Nick, Tara, Selda

Lab Lunch 2017/06/02
Left to right: Matt, Miranda, Natasha, Peyton, Ryan, Carolyn, Randall, Mara, Jon, Steve, Alex

For more, see personnel

Recent Publications

For more, see publications

Research

The research group of Dr. Miranda M. Lim is a part of the VA Portland Health Care System, with joint appointments at OHSU in the Departments of Medicine (Division of Pulmonary & Critical Care Medicine), Neurology, Behavioral Neuroscience and the Oregon Institute of Occupational Health Sciences.

Our research goals are to discover how sleep modulates processes in the developing brain and in neurodegenerative disease, and to directly translate basic sleep research findings in rodent models into the clinical practice of neurology and sleep medicine.

Ongoing research projects

The Lim Laboratory is interested in the interface between sleep and common neurological disorders, such as traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), autism, and Alzheimer's disease. We analyze EEG data for sleep, oscillations, and other quantitative markers in order to identify biomarkers that predict disease trajectories and response to treatment. We also manipulate sleep quality and sleep amounts to assess the function of sleep in the progression of these disorders. Our research moves seamlessly from animal models to clinical research in human subjects, and back to the bench again, with the ultimate goal of designing interventions to optimize sleep and enable better treatments in these vulnerable populations.

Currently, there are opportunities to participate in both animal and human studies in the lab.

  1. The animal studies include rodent models and in vivo sleep/wake EEG recordings. The work entails EEG signal processing, sleep scoring, processing brain tissue, and/or scoring behavioral videos.
  2. The human studies span small pilot studies on TBI/PTSD to large multi-PI studies. The work entails consenting subjects, administering questionnaires, analyzing physiological data (EEG or other PSG signals), data entry, and/or analysis of large datasets.

Techniques used include fluid percussion injury, controlled cortical impact, chronic in vivo EEG/EMG recording in freely behaving animals, quantitative EEG signal processing, microdialysis, immunohistochemistry, electron microscopy, behavior testing in mice and voles, and human sleep studies.

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start.txt · Last modified: 2018/07/12 13:52 by mara