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The research group of Dr. Miranda M. Lim is a part of the VA Portland Health Care System, with joint appointments at OHSU in the Departments of Medicine (Division of Pulmonary & Critical Care Medicine), Neurology, Behavioral Neuroscience and the Oregon Institute of Occupational Health Sciences.
Our research goals are to discover how sleep modulates processes in the developing brain and in neurodegenerative disease, and to directly translate basic sleep research findings in rodent models into the clinical practice of neurology and sleep medicine.
The Lim Laboratory is interested in the interface between sleep and common neurological disorders, such as traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), autism, and Alzheimer's disease. We analyze EEG data for sleep, oscillations, and other quantitative markers in order to identify biomarkers that predict disease trajectories and response to treatment. We also manipulate sleep quality and sleep amounts to assess the function of sleep in the progression of these disorders. Our research moves seamlessly from animal models to clinical research in human subjects, and back to the bench again, with the ultimate goal of designing interventions to optimize sleep and enable better treatments in these vulnerable populations.
Currently, there are opportunities to participate in both animal and human studies in the lab.
Techniques used include fluid percussion injury, controlled cortical impact, chronic in vivo EEG/EMG recording in freely behaving animals, quantitative EEG signal processing, microdialysis, immunohistochemistry, electron microscopy, behavior testing in mice and voles, and human sleep studies.